Auteur Topic: Borstvoeding verlaagt kans op hooikoorts en obesitas bij kinderen  (gelezen 44 keer)

tine

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Borstvoeding verlaagt kans op hooikoorts en obesitas bij kinderen
« Gepost op: april 09, 2021, 13:03:42 »
Baby's die borstvoeding krijgen, hebben later, als ze 5 jaar oud zijn, minder kans op hooikoorts en obesitas, blijkt uit onderzoek. Voor de kans op coeliakie maakt het niet uit; baby's die borstvoeding krijgen, ontwikkelen net zo vaak coeliakie als baby's die flesvoeding krijgen. Ook de kans op het ontstaan van diabetes type 1 blijft gelijk. Dit is onderzocht bij duizenden baby's die de genen hebben voor coeliakie en diabetes type 1. Binnen de TEDDY studie worden deze baby's jarenlang gevolgd en wordt hun ontwikkeling en gezondheid in de gaten gehouden.


10.1093/ajcn/nqab065. Online ahead of print. 2021 Apr 8;nqab065.
Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study
Sandra Hummel 1, Andreas Wei▀ 1, Ezio Bonifacio 2, Daniel Agardh 3, Beena Akolkar 4, Carin A Aronsson 3, William A Hagopian 5, Sibylle Koletzko 6 7, Jeffrey P Krischer 8, ┼ke Lernmark 3, Kristian Lynch 8, Jill M Norris 9, Marian J Rewers 10, Jin-Xiong She 11, Jorma Toppari 12 13, Ulla Uusitalo 8, Kendra Vehik 8, Suvi M Virtanen 14 15 16 17, Andreas Beyerlein 1, Anette-G Ziegler 1, TEDDY Study Group

PMID: 33831944 DOI: 10.1093/ajcn/nqab065

Background: Breastfeeding has beneficial effects on numerous health outcomes.

Objectives: We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.

Methods: Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of developing autoimmunity or allergy were assessed using Cox proportional hazards models, and the risk of obesity at 5.5 y of age was assessed using logistic regression with adjustment by the propensity score.

Results: Breastfeeding duration was not associated with a lower risk of either islet or transglutaminase autoimmunity (any breastfeeding >6 mo, adjusted HR: 1.07; 95% CI: 0.96, 1.19; exclusive breastfeeding >3 mo, adjusted HR: 1.03; 95% CI: 0.92, 1.15). Exclusive breastfeeding >3 mo was associated with a decreased risk of seasonal allergic rhinitis (adjusted HR: 0.70; 95% CI: 0.53, 0.92; P < 0.01). Any breastfeeding >6 mo and exclusive breastfeeding >3 mo were associated with decreased risk of obesity (adjusted OR: 0.62; 95% CI: 0.47, 0.81; P < 0.001; and adjusted OR: 0.68; 95% CI: 0.47, 0.95; P < 0.05, respectively).

Conclusions: Longer breastfeeding was not associated with a lower risk of childhood (islet or transglutaminase) autoimmunity in genetically at-risk children but was associated with decreased risk of seasonal allergic rhinitis and obesity at 5.5 y of age. 13, Ulla Uusitalo 8, Kendra Vehik 8, Suvi M Virtanen 14 15 16 17, Andreas Beyerlein 1, Anette-G Ziegler 1, TEDDY Study Group
PMID: 33831944 DOI: 10.1093/ajcn/nqab065

Background:

Breastfeeding has beneficial effects on numerous health outcomes.

Objectives:

We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.

Methods:

Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of developing autoimmunity or allergy were assessed using Cox proportional hazards models, and the risk of obesity at 5.5 y of age was assessed using logistic regression with adjustment by the propensity score.

Results:

Breastfeeding duration was not associated with a lower risk of either islet or transglutaminase autoimmunity (any breastfeeding >6 mo, adjusted HR: 1.07; 95% CI: 0.96, 1.19; exclusive breastfeeding >3 mo, adjusted HR: 1.03; 95% CI: 0.92, 1.15). Exclusive breastfeeding >3 mo was associated with a decreased risk of seasonal allergic rhinitis (adjusted HR: 0.70; 95% CI: 0.53, 0.92; P < 0.01). Any breastfeeding >6 mo and exclusive breastfeeding >3 mo were associated with decreased risk of obesity (adjusted OR: 0.62; 95% CI: 0.47, 0.81; P < 0.001; and adjusted OR: 0.68; 95% CI: 0.47, 0.95; P < 0.05, respectively).

Conclusions:

Longer breastfeeding was not associated with a lower risk of childhood (islet or transglutaminase) autoimmunity in genetically at-risk children but was associated with decreased risk of seasonal allergic rhinitis and obesity at 5.5 y of age.
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