Auteur Topic: Moeders met coeliakie en zwangerschapsdiabetes krijgen vaker een groot kind  (gelezen 233 keer)

tine

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Zwangerschapsdiabetes komt voor bij 1 op de 20 zwangerschappen. Het kan meestal goed behandeld worden. En na de bevalling verdwijnt het doorgaans. Er zijn weinig verschillen tussen moeders met en zonder coeliakie die zwangerschapsdiabetes hebben. Op één ding na: de baby van een moeder met coeliakie is vaak wat groter. Misschien omdat een glutenvrij dieet meer koolhydraten bevat, en weinig vezels en eiwitten, menen onderzoekers uit Italië. Ze baseren zich op gegevens van 20 moeders met coeliakie en 40 moeders zonder coeliakie, allebei de groepen hadden zwangerschapssuiker. Eigenlijk is een grotere groep nodig om zeker te weten dat de uitkomsten geen toeval zijn, relativeren ze de uitkomsten.


Int J Endocrinol
. 2020 Oct 16;2020:5295290. doi: 10.1155/2020/5295290. eCollection 2020.
Celiac Disease and Pregnancy Outcomes in Patients with Gestational Diabetes Mellitus
Maria Grazia Dalfrà 1, Gloria Giovanna Del Vescovo 1, Silvia Burlina 1, Ilaria Baldan 1, Silvia Pastrolin 1, Annunziata Lapolla 1

PMID: 33178268 PMCID: PMC7607885 DOI: 10.1155/2020/5295290

Aim: Gestational diabetes mellitus (GDM) and celiac disease, if not diagnosed and properly treated, are associated with adverse outcomes of pregnancy. The aim of our study was to examine pregnancies complicated by GDM in celiac and nonceliac women in terms of their metabolic parameters and maternal and fetal outcomes.

Methods: The study involved 60 women with GDM, 20 with and 40 without celiac disease. Maternal clinical and metabolic parameters (glucose and insulin levels in the oral glucose tolerance test (OGTT), fasting plasma glucose, HbA1c, lipid profile, prepregnancy BMI, gestational weight gain, and chronic diseases), pregnancy outcomes (gestational hypertension, pre-eclampsia, eclampsia, time, and mode of delivery), and fetal parameters (weight and length at birth, and neonatal complications) were recorded.

Results: The two groups did not differ significantly in maternal parameters other than blood glucose levels at 120' in the diagnostic OGTT (141.2 ± 35.2 vs 161.2 ± 35.4, mg/dl, p=0.047), prepartum cLDL (127.2 ± 43.5 vs 179.6 ± 31.7 mg/dl, p ≤ 0.001), and total cholesterol (229.0 ± 45.9 vs 292.5 ± 42.1 mg/dl, p ≤ 0.001), which were significantly lower in celiac women than in nonceliac controls. Children born from celiac women had a significantly higher birth weight (3458.1 ± 409.8 vs 3209.0 ± 432.7 g, p=0.044) and ponderal index (2.89 ± 0.32 vs 2.66 ± 0.25 g/cm3, p=0.006) and were more likely to be large for gestational age (27.8% vs 2.5%, p=0.012). Analyzing the composition of the celiac and nonceliac women's diet showed that, for the same amount of kilocalories, the gluten-free diet was associated with a slight increase in the amount of carbohydrates (49.75% vs 48.54%) and a reduction in the amount of protein (21.10% vs 23.31%) and especially of fiber (9.84% vs 12.71%).

Conclusions: Celiac women with GDM have much the same pregnancy outcomes as nonceliac women with GDM, except for fetal overgrowth. Gluten-free food, being richer in carbohydrates and less rich in fiber and protein, could have a role in fetal growth in celiac women.
Mijn zoon (20) en ik eten allebei glutenvrij. Wij zijn extreem gevoelig voor sporen van gluten (via besmetting, tarwe-derivaten en hulpstoffen). Ik ben wetenschapsredacteur voor het Glutenvrij Magazine van de NCV.