Auteur Topic: CoeliakiepatiŽnten hebben iets grotere kans op onregelmatige hartslag  (gelezen 426 keer)

tine

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CoeliakiepatiŽnten hebben iets vaker te maken met een onregelmatige hartslag (boezemfibrilleren) dan mensen zonder coeliakie. De kans is 1,4 keer zo groot. Dat blijkt na bestudering van onderzoek op dit gebied, verricht door cardiologen. Waarschijnlijk heeft dit te maken met een verhoogde gevoeligheid voor ontstekingen onder patiŽnten met coeliakie, schrijven de auteurs.

Cureus. 2020 Feb 14;12(2):e6997. doi: 10.7759/cureus.6997.
Celiac Disease and Risk of Atrial Fibrillation: A Meta-analysis and Systematic Review.
Hidalgo DF1, Boonpheng B2, Nasr L3, Sikandar S4, Hidalgo J5, Intriago M6.

Several studies have found celiac disease may be associated with a variety of cardiac manifestations. Atrial fibrillation (AF) is one of the most common arrhythmias that can cause significant morbidity. However, the risk of atrial fibrillation in patients with celiac disease according to epidemiological studies remains unclear. The aim of this meta-analysis study is to assess the risk of atrial fibrillation in patients diagnosed with celiac disease compared to controls. Methods A systematic literature review was conducted in MEDLINE, EMBASE, Cochrane databases from inception through December 2017 to identify studies that evaluated the risk of atrial fibrillation in patients with celiac disease. We included randomized controlled trial, cross sectional and cohort studies that reported the odds ratio, relative risk, hazard ratio, and standardized incidence ratio comparing the risk of developing atrial fibrillation among patients with celiac disease, versus patients without celiac disease as control. The Newcastle-Ottawa scale was used to determine the quality of the studies. Effect estimates from individual studies were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird. Results Celiac disease is an autoimmune condition. This inflammatory state predisposes patients to develop AF. After a review of the literature, four observational studies with a total of 64,397 participants were enrolled. The association between celiac disease and increased risk of atrial fibrillation was significant, with a pooled OR of 1.38 (95% CI: 1.01-1.88). No publication bias as assessed by the funnel plots and Egger's regression asymmetry test with p = 0.54. However, the heterogeneity of the included studies was high (I2 = 96). Conclusion A significant association between celiac disease and risk of atrial fibrillation was reported in this study. There is a 38% increased risk of atrial fibrillation. Additional studies are needed to clarify the mechanistic link between atrial fibrillation and celiac disease. Some of the limitations of this study are that all were observational studies, some were medical registry-based and there was high heterogeneity between studies.


PMID: 32206461 PMCID: PMC7077104 DOI: 10.7759/cureus.6997
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