Auteur Topic: Vergroot keizersnee kans op coeliakie op latere leeftijd?  (gelezen 414 keer)

tine

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Vergroot keizersnee kans op coeliakie op latere leeftijd?
« Gepost op: maart 29, 2020, 18:46:51 »
Verrassend: baby's die geboren worden met een keizersnee, zowel gepland als spoed, hebben iets vaker coeliakie tegen de tijd dat ze 40 jaar zijn of ouder, vergeleken met baby's die via de natuurlijke weg geboren worden, via de vagina. Hetzelfde geldt voor reuma, diabetes, Crohn en Colitis (de laatste twee zijn ontstekingsziekten van de darmen). Deze ziektes komen op latere leeftijd ook iets vaker voor bij de groep die via een keizersnee geboren is. Dit blijkt uit onderzoek in Denemarken onder ruim 2,5 miljoen baby's die tussen 1973 en 2016 geboren zijn. Of het één het gevolg is van het ander is niet bekend. Het verschil tussen beide groepen (vaginale geboorte en een keizersnee) is trouwens erg klein.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073427/

Clin Epidemiol. 2020; 12: 287–293.
Published online 2020 Mar 9. doi: 10.2147/CLEP.S229056

Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
Vibeke Andersen,1,2,3 Sören Möller,4 Peter Bjødstrup Jensen,4 Frederik Trier Møller,5,6 and Anders Green4

Chronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth and onwards. In this study, we use data from the national Danish health registers to evaluate the risk of developing four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases.

Methods
A national population-based registry study. Data from the Danish Medical Birth Registry and the Danish National Patient Registry from January 1973 to March 2016 were linked at a personal level to evaluate any potential associations between caesarean section and development of Inflammatory bowel diseases, rheumatoid arthritis, coeliac disease and diabetes mellitus among the offspring. A model adjusted for parental age at birth, decade of birth, gender of child, and parents’ chronic inflammatory disease status was used.

Results
This register-based national cohort study of 2672708 children with information on delivery mode found an increased risk of diabetes, arthritis, coeliac disease, and inflammatory bowel disease for both girls and boys after caesarean section compared with vaginal delivery. The higher risk was present at least 40 years after delivery. In a subgroup analysis, both acute and elective caesarean section was associated with an increased risk of developing a chronic inflammatory disease.

Conclusions
Being born by caesarean section leads to increased host susceptibility for chronic inflammatory diseases that last for decades. This finding should be further addressed in future studies with the aim to support the development of new strategies for prevention, treatment, and maybe even cure.


Key Messages
This study found an increased risk of four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases (inflammatory bowel diseases, rheumatoid arthritis, coeliac disease, and diabetes mellitus) both as separate diseases and when combined as chronic inflammatory diseases, in children after delivery by caesarean section compared to vaginal delivery.

The increased risk was detectable in the offspring for at least 40 years of follow-up from birth for all four diseases.

The risk was increased for both girl and boys for all four diseases.

The risk of developing a chronic inflammatory disease was increased for both elective and acute caesarean section, as compared with vaginal delivery.
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