Auteur Topic: Kinderen met coeliakie hebben twee keer zoveel kans op epilepsie  (gelezen 213 keer)

tine

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Kinderen met coeliakie hebben twee keer zoveel kans op epilepsie
« Gepost op: februari 02, 2020, 21:47:19 »
Uit onderzoek blijkt dat bij Italiaanse kinderen met coeliakie de kans op epilepsie verdubbeld is (2,6 % ipv 1,3 %). Meestal wordt epilepsie eerder ontdekt dan coeliakie. Meisjes met coeliakie hebben vaker epilepsie dan jongens.


Eur J Neurol. 2020 Jan 29. doi: 10.1111/ene.14160. [Epub ahead of print]
The risk of epilepsy in children with celiac disease: a population-based cohort study.
Canova C1, Ludvigsson J2,3,4,5, Amidei CB1, Zanier L6, Zingone F7.

OBJECTIVE:
To estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references.

METHODS:
The cohort consists of 213,635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). We identified 1,215 individuals affected by CD and 6,075 reference individuals matched by sex and age. Epilepsy was defined by means of hospital diagnosis or drug prescriptions. Conditional logistic regression was used to estimate the odds ratios (ORs) of having epilepsy among individuals with CD, before CD diagnosis and in the entire period, compared with those of their matched references. Cox regression was used to calculate the hazard ratios (HRs) for epilepsy diagnosed after CD diagnosis. Different definitions of epilepsy were used for sensitivity analyses.

RESULTS:
Thirty-one (2.6%) individuals with CD and 78 (1.3%) reference individuals had epilepsy (adjusted OR: 2.03 95%CI: 1.33-3.10). The risk of epilepsy was increased prior to CD (adjusted OR: 2.29; 95%CI: 1.33-3.94), with similar estimates after CD diagnosis (adjusted HR 1.96; 95%CI: 0.95-4.02). The increased risk of epilepsy was not explained by a peak in epilepsy diagnosis just around CD diagnosis. Sex stratification found a significantly higher risk of epilepsy among female individuals with CD. Sensitivity analyses confirmed the positive association between CD and epilepsy.

CONCLUSION:
Children and youths with CD were at increased risk of epilepsy. Patients with epilepsy without a clear etiology should be screened for CD since an early diagnosis and treatment might improve the response to antiepileptic therapies. 
Mijn zoon (20) en ik eten allebei glutenvrij. Wij zijn extreem gevoelig voor sporen van gluten (via besmetting, tarwe-derivaten en hulpstoffen). Ik ben wetenschapsredacteur voor het Glutenvrij Magazine van de NCV.