Auteur Topic: Glutenvrij eten helpt bij sommige mensen met schizofrenie  (gelezen 488 keer)

tine

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Glutenvrij eten helpt bij sommige mensen met schizofrenie
« Gepost op: april 09, 2019, 21:29:56 »
Sommige mensen met schizofrenie hebben baat bij een glutenvrij dieet, blijkt uit een onderzoek onder 14 proefpersonen in de VS. Als ze geen gluten eten, kunnen ze psychisch beter functioneren en hebben ze minder darmklachten. Er is geen verschil in cognitief functioneren. De proefpersonen hadden geen coeliakie maar wel anti gliadine antistoffen (AGA IgG) in hun bloed (die antistoffen zien artsen regelmatig bij neurologische klachten door gluten). Het plan is om een grootschaliger onderzoek te doen, om te zien of de gevonden effecten ook bij grotere groepen optreden en geen toeval zijn.

Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study

(PMID:30938127)

Kelly DL 1 ,  Demyanovich HK 1 ,  Rodriguez KM 1 ,  Ciháková D 1 ,  Talor MV 1 ,  McMahon RP 1 ,  Richardson CM 1 ,  Vyas G 1 ,  Adams HA 1 ,  August SM 1 ,  Fasano A 1 ,  Cascella NG 1 ,  Feldman SM 1 ,  Liu F 1 ,  Sayer MA 1 ,  Powell MM 1 ,  Wehring HJ 1 ,  Buchanan RW 1 ,  Gold JM 1 ,  Carpenter WT 1 ,  Eaton WW 1 

Journal of Psychiatry & Neuroscience : JPN [27 Mar 2019, 44(3):1-9]

Background:Approximately one-third of people with schizophrenia have elevated levels of anti-gliadin antibodies of the immunoglobulin G type (AGA IgG) — a higher rate than seen in healthy controls. We performed the first double-blind clinical trial of gluten-free versus gluten-containing diets in a subset of patients with schizophrenia who were positive for AGA IgG. Methods:In this pilot feasibility study, 16 participants with schizophrenia or schizoaffective disorder who had elevated AGA IgG (≥ 20 U) but were negative for celiac disease were admitted to an inpatient unit for a 5-week trial. All participants received standardized gluten-free meals and were randomized in a double-blind fashion to receive a shake containing 10 g of gluten flour or 10 g of rice flour each day. Participants were rated for psychiatric, cognitive and gastrointestinal symptoms at baseline and endpoint. Results:Of the 16 participants, 14 completed the 5-week trial (2 discontinued early for administrative reasons). Compared with participants on the gluten-containing diet, participants on the gluten-free diet showed improvement on the Clinical Global Impressions scale (Cohen d = –0.75) and in negative symptoms (Cohen d = –0.53). We noted no improvement in positive or global cognitive symptoms, but did observe an improvement in attention favouring the gluten-free diet (Cohen d = 0.60). Robust improvements in gastrointestinal adverse effects occurred in the gluten-free group relative to the glutencontaining group. Adverse effects were similar between groups. Limitations:This study was limited by its small sample size; larger studies are needed. Conclusion:This feasibility study suggests that removal of gluten from the diet is associated with improvement in psychiatric and gastrointestinal symptoms in people with schizophrenia or schizoaffective disorder.
Mijn zoon (19) en ik eten allebei glutenvrij. Wij zijn extreem gevoelig voor sporen van gluten (via besmetting, tarwe-derivaten en hulpstoffen). Ik ben wetenschapsredacteur voor het Glutenvrij Magazine van de NCV.