Auteur Topic: Familie van coeliakiepatient heeft meer kans op een auto-immuunziekte  (gelezen 1695 keer)

tine

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Familie van coeliakiepatient heeft meer kans op een auto-immuunziekte
« Gepost op: februari 04, 2015, 09:27:27 »
Eerstegraadsfamilieleden van een coeliakiepatient hebben meer kans op een auto-immuunziekte dan mensen zonder coeliakie in de familie. De kans op een auto-immuunziekte onder de algemene bevolking is 3%, bij mensen met een broer, zus of partner met coeliakie is die kans 3,9%. De auto-immuunziekten die gerelateerd zijn aan coeliakie zijn:
- de ziekte van Crohn
- type 1 diabetes
- schildklierziekten
- psoriasis
- reuma
- sarcoidosis (vooral longklachten)
- lupus
- ulceratieve colitis

Dit heeft men onderzocht door databases te onderzoeken van pathologische laboratoria in Zweden, waarbij patienten met coeliakie werden gezocht en waarbij ook de ziektegeschiedenis van familieleden in kaart kon worden gebracht. Ook het Groningse ziekenhuis UMCG, gespecialiseerd in Genetica, heeft deelgenomen aan het onderzoek.



Clin Gastroenterol Hepatol. 2015 Jan 30. pii: S1542-3565(15)00112-3. doi: 10.1016/j.cgh.2015.01.026. [Epub ahead of print]

Autoimmune Disease in First-degree Relatives and Spouses of Individuals with Celiac Disease.

Emilsson L1, Wijmenga C2, Murray JA3, Ludvigsson JF4.


Author information

1Primary care research unit, Vårdcentralen Värmlands Nysäter, Värmland County, Sweden; Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Norway. Electronic address: lojsankik@hotmail.com.
2University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
3Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.


BACKGROUND & AIMS:


First-degree relatives of individuals with celiac disease are at increased risk for this disorder, but little is known about their risk for other autoimmune diseases. We assessed the risk of non-celiac autoimmune disease first-degree relatives and spouses of people with celiac disease.

METHODS:

We identified individuals with celiac disease by searching computerized duodenal and jejunal biopsies, collected from 1969 through 2008, at 28 pathology departments in Sweden. Celiac disease was identified based on biopsy reports of villous atrophy (equal to Marsh grade 3; n=29,096). Individuals with celiac disease were matched with up to 5 controls (people without celiac disease) for sex, age, county, and calendar year (144,522 controls total). Through Swedish healthcare registries, we identified all first-degree relatives (fathers, mothers, siblings, and offspring) and spouses of individuals with celiac disease (n=84,648) and controls (n=430,942). We used Cox regression analysis to calculate hazard ratios (HRs) for non-celiac autoimmune disease (Crohn's disease, type 1 diabetes mellitus, hypothyroidism, hyperthyroidism, psoriasis, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, or ulcerative colitis) in these groups.

RESULTS:

During the follow-up period (median 10.8 y), 3333 of the first-degree relatives of patients with celiac disease (3.9%) and 12,860 relatives of controls (3.0%) had an autoimmune disease other than celiac disease. First-degree relatives of people with celiac disease were at increased risk of non-celiac autoimmune disease, compared with controls (HR=1.28; 95% confidence interval, 1.23-1.33), as were spouses (HR=1.20; 95% CI, 1.06-1.35). Risk estimates for non-celiac autoimmune disease did not differ between first-degree relatives and spouses of individuals with celiac disease (interaction test: P=.11). HRs for celiac disease were highest in the first 2 y of follow-up.

CONCLUSION:

First-degree relatives and spouses of individuals with celiac disease are at increased risk of non-celiac autoimmune disease. In addition to genetic factors, environmental factors and ascertainment bias might contribute to the increased risk of autoimmunity in first-degree relatives of individuals with celiac disease.

Bron: Pubmed
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