Auteur Topic: Volledig artikel: Recent advances in celiac disease (Canadees onderzoek)  (gelezen 1052 keer)

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Volledig artikel (Canadees onderzoek)
World J Gastroenterol. 2011 May 14; 17(18): 2259-2272


Citaat
Recent advances in celiac disease
Hugh James Freeman, Division of Gastroenterology, University of British Columbia, Vancouver, BC, V6T 1W5, Canada
Angeli Chopra, Alan BR Thomson, Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, AB T6G 2M7, Canada
Michael Tom Clandinin, Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, AB T6G 2M7, Canada

Abstract
Celiac disease now affects about one person in a hundred in Europe and North America.
In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease.
This review will be of use to all internists, pediatricians and gastroenterologists.

INTRODUCTION

EPIDEMIOLOGY

GENETICS

PATHOGENESIS

SEROLOGY

MUCOSAL HISTOLOGY

CLINICAL PHENOTYPES

CLINICAL ASSOCIATIONS

TREATMENT

REFRACTORY DISEASE

CONCLUSION
Celiac disease is being increasingly diagnosed because of the recognition that the disease may be present without significant intestinal symptoms, may be associated with other autoimmune disorders and may be suspected from serological screening.
Definition of the disease includes an intestinal biopsy before treatment with a GFD along with documentation of a definitive GFD response.
In some patients, this may necessitate further intestinal biopsy after a period on a GFD.
Serological testing may be useful in providing additional evidence that CD is present and may be useful in some patients to assess GFD compliance.
Recent studies focused on the genetic basis and pathogenesis of CD have emerged to improve understanding of the complex molecular alterations that occur with CD.

Volledig artikel:
http://www.wjgnet.com/1007-9327/full/v17/i18/2259.htm






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