Auteur Topic: Over coeliakietesten: The 7th International Congress on Autoimmunity  (gelezen 1262 keer)

ine

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Over coeliakietesten: The 7th International Congress on Autoimmunity
« Gepost op: augustus 06, 2010, 16:38:39 »
Hieronder informatie over coeliakie op het gehouden congres:
7th International Congress on Autoimmunity
May 5 – 9, 2010

NB
Hier staan dus ook andere onderzoeken in vermeld.



Vanaf pagina 16 t/m 20 over Coeliakie
Citaat
Pagina 16:
High sensitivity of anti-deamidated gliadin peptide IgG
antibodies for diagnosis of celiac disease in children

L. Mozo, E. Escanlar, C. Gutiérrez
Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain

Table 1:  Anti-dGp IgG showed the highest diagnostic performance for CD
Table 2:  Anti-dGp IgG performed better in CD children aged < 5 years than
              in older patients.
Figure 1: Levels of anti-Glia IgA and anti-dGp are inversely correlated
              with age.

Pagina 17:
Evaluation of a new fluorescent enzyme immunoassay in celiac disease diagnosis based on
the use of deamidated gliadin peptides

E. Vergara Prieto, M.L. Vargas Pérez, I. Alcalá Peña, S. Gordillo Vázquez, N. Román Pinto, J. Melero Ruiz
Immunology and Genetic Service, University Hospital of Badajoz, Spain

Figure 1:  ROC Curve analysis and test performance for deamidated and
              native gliadin peptide antibodies

Pagina 18:
Good sensitivity of tests for antibodies to deamidated gliadin peptides in children – correlation with jejunal morphology

M. Viander1, P. Arikoski2, A. Lammi3, A. Hinkkanen4, J. Ilonen5
1 Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland, 2 Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland, 3
Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland, 4 A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio,
Finland, 5 Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland and Immunogenetics Laboratory, University of Turku, Turku, Finland

Table 1:  Sensitivity of different tests in 33 children with celiac disease.
Table 2:  Different antibodies in six children with suspected CD
              but negative  biopsy – suggesting a latent CD?
Figure 1: A significant difference in the levels of antibodies in children with
              severe villous atrophy (n=18) compared to those with only partial
              or moderate lesions (n=15) in gliadin and EMA tests but not
              in tTG tests.


Pagina 20:
Diagnostic performance of IgG anti-DGP assays is comparable to IgA anti-tTG in celiac disease

Vermeersch P Laboratory Medicine, University Hospitals Leuven, Belgium

Of the 4 IgG anti-DGP assays, the Inova assay had the highest area under the curve and the best sensitivity (together with the Phadia assay)
and specificity.
The diagnostic performance of the IgG anti-DGP assays and the IgA anti-tTG assays in pediatric patients was better than the diagnostic performance of
the 2 IgG anti-tTG assays, the IgA anti-gliadin assay and the IgG anti-gliadin assay.

Zie de tabel


Link:
http://www.phadia.se/upload/Autoimmunity/EliA%20Journal/Files/EJE_SE_2010_web2.pdf





Groeten, Ine